Water soluble xanthylium derivative substrates

C - Chemistry – Metallurgy – 07 – K

Patent

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530/5.04, 150/15

C07K 5/04 (2006.01) C07K 5/083 (2006.01) C07K 5/097 (2006.01) C12Q 1/37 (2006.01) C12Q 1/56 (2006.01)

Patent

CA 1276391

ABSTRACT Water soluble xanthylium derivative substrates of rhodamine 110 and rhodol permit spectrophotometric and fluorescent measurements of trypsin-like enzymes without the addition of organic solvent additives and/or special water solubilizing agents. These novel substrates exhibit increased sensitivity for determining low levels of activity of trypsin-like enzymes such as proteolytic enzymes, cofactors, activators, antiactivators, and inhibitors. These substrates can be substituted for fibrinogen to monitor the pathways of blood coagulation.

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