Water-swellable polymers

Details Water-swellable polymers Water-swellable polymers

C - Chemistry, Metallurgy

08

G

C08G 18/48 (2006.01) A61K 9/02 (2006.01) A61K 47/34 (2006.01) C08G 18/32 (2006.01) C08G 18/66 (2006.01) C08G 18/75 (2006.01)

Patent

CA 2495341

A water-swellable linear polyurethane polymer is formed by reacting a polyethylene oxide (e.g. PEG 4000 to 35,000), a difunctional compound (e.g. a diamine or diol such as 1,10-decanediol) with a diisocyanate. The ratio of the three components is generally in the range 0.1-1.5 to 1 to 1.1 - 2.5. The polyurethane is water-swellable in the range 300 to 1700 % and soluble in certain organic solvents such as dichloromethane. It can be loaded with pharmaceutically active agents, particularly of high molecular weight, to produce controlled release compositions, such as pessaries etc.

L'invention concerne un polymère de polyuréthanne linéaire gonflable dans l'eau. Ce polymère est formé par réaction d'un oxyde polyéthylène (p. ex. PEG 4000 à 35,000), un composé difonctionnel (p. ex. un diamine ou diol tel qu'un 1,10-décanédiol) et un diisocyanate. Le rapport des trois composés est généralement compris entre 0,1-1,5 à 1 à 1,1 2,5. Le polyuréthanne est gonflable dans l'eau entre 300 et 1700 % et est soluble dans certains solvants organiques tels que le dichlorométhane. Il peut être chargé avec des agents pharmaceutiquement actifs, en particulier à poids moléculaire élevé, pour produire des compositions à libération contrôlée, telles que notamment des pessaires.

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