Ws-9326a, ws-9326b and their derivatives

Details Ws-9326a, ws-9326b and their derivatives Ws-9326a, ws-9326b and their derivatives

C - Chemistry, Metallurgy

12

P

167/179, 195/86,

C12P 1/06 (2006.01) A61K 35/74 (2006.01) A61K 38/08 (2006.01) C07G 11/00 (2006.01) C12N 1/20 (2006.01) C12P 21/04 (2006.01)

Patent

CA 1338261

Compounds identified as WS-9326A and WS-9326B which are obtained by culturing a WS-9326A and/or WS-9326B producing strain belonging to the genus Streptomyces in a nutrient medium. Salts thereof can also be obtained. These compounds or salts thereof can also be acylated to produce acyl derivatives. These compounds are useful as substance pantagonism, neurokinin A (substance K) antag- onism and are therefore useful for the treatment and prevention of asthma. The use of a compound as identified above as well as a biologically pure culture of the micro- organism Streptomyces violaceoniger No. 9326 (FERM BP-1667) are also disclosed.

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