Xanthine compounds

Details Xanthine compounds Xanthine compounds

C - Chemistry, Metallurgy

07

D

167/220, 260/242

C07D 473/02 (2006.01) A61K 31/52 (2006.01) C07D 473/06 (2006.01) C07D 473/08 (2006.01) C07D 473/20 (2006.01) C07D 473/22 (2006.01)

Patent

CA 2024381

Novel xanthine compounds represented by the following formula: Image wherein each of R1, R and R3 independently represents hydrogen or lower alkyl; each of X1 and X independently represents oxygen or sulfur; and Q represents: Image Image Image , , , Image , Image or Image where Image represents a single bond or a double bond; Y represents a single bond or alkylene, n represents 0 or 1, each of W1 and W independently represents hydrogen, lower alkyl or amino, Z represents -CH2-, -O-, -S- or -NH-; provided that when Q is , then R1, R and R3 are not Image simultaneously methyl; and pharmaceutically acceptable salts thereof have a diuretic effect, a renal-protecting effect and a bronchodilatory effect. - 52 - The compounds are useful as a diuretic, a renal- protecting agent and bronchodilator.

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