Xanthine derivatives

Details Xanthine derivatives Xanthine derivatives

C - Chemistry, Metallurgy

07

D

C07D 473/06 (2006.01) A61K 31/52 (2006.01) C07D 473/04 (2006.01)

Patent

CA 2120677

There is provided a novel xanthine Compound(I) (see formula I) wherein R1 and R2 are the same or different and each represent hydroxy-substituted, oxo-substituted or unsubstituted lower alkyl, Y is a single bond or alkylene, and Q is (see formula II or see formula III) wherein R3 and R4 are the same or different and each represent hydrogen or hydroxy, n is 0 or 1; provided that when both of R3 and R4 are hydrogen, at least one of R1 and R2 is hydroxy-substituted or oxo-substituted lower alkyl; or a pharmaceutically acceptable salt thereof. The xanthine compound has adenosine A1 receptor antagonizing activity, and thus shows diuretic effect, renal-protecting effect, bronchodilatory effect, cerebral function improving effect and anti-dementia effect.

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