Xanthine derivatives, the preparation thereof and their use...

Details Xanthine derivatives, the preparation thereof and their use... Xanthine derivatives, the preparation thereof and their use...

C - Chemistry, Metallurgy

07

D

C07D 473/04 (2006.01) A61P 5/50 (2006.01) C07D 473/06 (2006.01) C07D 519/00 (2006.01)

Patent

CA 2505389

The present invention relates to substituted xanthines of general formula (see formula I), wherein R1 to R4 are defined as in claim 1, the tautomers, the stereoisomers, the mixtures thereof, the prodrugs thereof and the salts thereof, which have valuable pharmacological properties, particularly an inhibitory effect on the activity of the enzyme dipeptidylpeptidase-IV (DPP-IV).

La présente invention concerne des xanthines substituées de formule générale (I), dans laquelle R?1¿ à R?4¿ sont tels que définis dans la revendication n·1, ainsi que les tautomères, stéréoisomères, mélanges, promédicaments et sels de celles-ci. Ces composés possèdent des propriétés pharmacologiques avantageuses, notamment une action inhibitrice sur l'activité de l'enzyme dipeptidylpeptidase-IV (DPP-IV).

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