Yeast heat shock protein 60 and analogs

Details Yeast heat shock protein 60 and analogs Yeast heat shock protein 60 and analogs

C - Chemistry, Metallurgy

12

N

530/15.04, 195/1

C12N 15/31 (2006.01) C07K 1/113 (2006.01) C07K 14/395 (2006.01) C12N 9/10 (2006.01) C12N 15/81 (2006.01)

Patent

CA 2001239

ABSTRACT A purified, biologically active yeast mitochondrial heat shock protein exhibiting an Mr of about 60K (hsp60) and its biologically active analogs exhibiting an Mr of 55K-65K are disclosed. Polynucleotide segments that encode hsp60 and its analogs are disclosed as are vectors containing the same, as well as transformed cells that contain the vectors. Methods of assembling non-functional protein subunits into a functional oligomeric protein complex and for converting an inactive form of a monomeric protein molecule or protein subunit molecule into an active form of the molecule are also disclosed. 9875M D-18M

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