Zero length cross-linking of proteins and related compounds

Details Zero length cross-linking of proteins and related compounds Zero length cross-linking of proteins and related compounds

C - Chemistry, Metallurgy

07

K

C07K 1/00 (2006.01)

Patent

CA 2458256

The invention relates to a method of cross-linking poly(amino acid) compounds (e.g. proteins, polypeptides, protein polymers, etc.) to each other or attaching such compounds to polyamino or polycarboxyl compounds. The method involves lyophilizing a solution of at least one poly(amino acid) compound, or at least one poly(amino acid) compound and a polyamino or polycarboxyl compound, maintaining the lyophilized solid under vacuum, heating the lyophilized solid under vacuum to an elevated temperature effective to cause cross-linking without denaturing of the poly(amino acid) compounds, and cooling the product and releasing the vacuum. The method produces cross- linking without the use of activating compounds or cross-linking molecules. The invention also relates to novel cross-linked products.

La présente invention concerne une technique de réticulation de composés poly(amino acide) (par exemple des protéines, des polypeptides, des polymères protéiniques, etc.) entre eux ou de liaison de ces composés à des composés polyamino ou polycarboxyle. Cette technique consiste à lyophiliser une solution d'au moins un composé poly(amino acide), ou d'au moins un composé poly(amino acide) et d'un composé polyamino ou polycarboxyle, à maintenir ce solide lyophilisé sous vide, à chauffer ce solide lyophilisé sous vide à une température élevée efficace pour entraîner une réticulation sans dénaturer les composés poly(amino acide), à refroidir ce produit et à rétablir la pression atmosphérique. Cette technique produit une réticulation sans qu'il soit nécessaire de recourir à des composés activateurs ou à des molécules de réticulation. Cette invention concerne aussi de nouveaux produits réticulés.

Affiliated with

Also associated with

Rating

Zero length cross-linking of proteins and related compounds does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Zero length cross-linking of proteins and related compounds, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Zero length cross-linking of proteins and related compounds will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFCA-PAI-O-1779852