Zinc finger binding domains for nucleotide sequence ann

Details Zinc finger binding domains for nucleotide sequence ann Zinc finger binding domains for nucleotide sequence ann

C - Chemistry, Metallurgy

07

K

C07K 14/47 (2006.01) C07K 7/06 (2006.01) C12N 15/12 (2006.01) C12N 15/63 (2006.01) C12N 15/85 (2006.01)

Patent

CA 2442293

Polypeptides that contain from 2 to 12 zinc finger-nucleotide binding regions that bind to nucleotide sequences of the formula (ANN)2-12 are provided. Polynucleotides that encode such polypeptides and methods of regulating gene expression with such polypeptides and polynucleotides are also provided.

Cette invention se rapporte à des polypeptides qui contiennent 2 à 12 régions de fixation de nucléotides à doigts de zinc, qui se fixent aux séquences nucléotidiques représentées par la formule (ANN)2-12. Des polynucléotides qui codent ces polypeptides et des procédés servant à réguler l'expression génique à l'aide de ces polypeptides et polynucléotides sont également décrits.

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