High level expression in e. coli of soluble mature hil-1beta...

Details High level expression in e. coli of soluble mature hil-1beta... High level expression in e. coli of soluble mature hil-1beta...

C - Chemistry, Metallurgy

12

N

530/13, 195/1.2,

C12N 15/12 (2006.01) C07K 14/545 (2006.01) C12N 1/20 (2006.01) C12N 15/72 (2006.01) C12P 21/02 (2006.01)

Patent

CA 1305080

TITLE BT-0009-A High Level Expression in E. coli of Soluble Mature hIL-1.beta. and Derivatives with Altered Biological Activity ABSTRACT Plasmid pUC8 and DNA coding for hIL-1.beta. are used to construct hybrid plasmids capabla of high level expression in E. coli of soluble proteins, including mature hIL-1.beta. and derivatives of mature hIL-1.beta. having amino acid substitutions and insertions at one or all of positions 1 to 4 at the amino terminus. Derivatives of hIL-1.beta. with alterations at the N-terminus have been produced which either enhanced or decreased bioactivity compared to native monocyte derived hIL-1.beta..

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