Process for preparing polypeptide derivatives

Details Process for preparing polypeptide derivatives Process for preparing polypeptide derivatives

C - Chemistry, Metallurgy

07

K

530/7.4, 167/103

C07K 14/62 (2006.01) A61K 38/00 (2006.01)

Patent

CA 1174973

2360.200/DA1 ToN/VMN 82-06-21 ABSTRACT Process for Preparing Insulin Derivatives The yield of threonineB30 derivatives of human insulin when amidating des(AlaB30)-insulin with a L-threonine derivative in a mixture of water and a water miscible organic solvent in the presence of trypsin is increased substantially when the content of water in the reaction mixture is between 30 and 10%. B13

408994

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