Prolinyl derivatives for treating thrombosis

C - Chemistry – Metallurgy – 07 – D

Patent

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Details

C07D 207/12 (2006.01) A61K 31/401 (2006.01) A61K 31/4025 (2006.01) A61P 7/02 (2006.01) C07D 403/12 (2006.01)

Patent

CA 2561057

The invention relates to novel compounds of formula (I), in which R, R1, R2, R3 and R4 are defined as cited in claim 1. Said compounds are inhibitors of the coagulation factor Xa and can be used for the prophylaxis and/or treatment of thromboembolic diseases and for the treatment of tumours.

L'invention concerne les nouveaux composés représentés par la formule (I) dans laquelle R, R?1¿, R?2¿, R?3¿ et R?4 ¿ont les significations données dans la revendication 1. Lesdits composés sont des inhibiteurs du facteur de coagulation Xa et peuvent être employés dans la prohylaxie et/ou la thérapie de maladies thromboemboliques, et dans le traitement de tumeurs.

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