Compositions for the reversal and detoxification of...

Details Compositions for the reversal and detoxification of... Compositions for the reversal and detoxification of...

A - Human Necessities

61

K

A61K 9/10 (2006.01) A61K 9/14 (2006.01) A61K 47/22 (2006.01) A61K 47/24 (2006.01) A61P 39/00 (2006.01)

Patent

CA 2672024

Methods of attenuating the toxic or medically undesirable effects of drugs and toxins in a human by administering to a human an injectable formulation comprised of a dispersion of particles comprised of reversed cubic or reversed hexagonal lyotropic liquid crystalline material. The particles absorb or adsorb or otherwise sequester and attenuate the effect of drugs and toxins, and may be used as a rescue or reversal agent, or as a prophylaxis. The invention is especially applicable in reversing adverse effects of local anesthetics inadvertently delivered systemically, and attenuating the therapeutic effects of general anesthetics in the course of treatment.

La présente invention concerne des procédés d'atténuation des effets toxiques ou médicalement indésirables des médicaments et des toxines chez un être humain par l'administration chez l'humain d'un formulation injectable comprise d'une dispersion de particules comprenant un matériel liquide cristallin lyotrope cubique inversé ou hexagonal inversé. Les particules absorbent ou adsorbent ou autrement séquestrent et atténuent l'effet des médicaments et des toxines et peuvent être utilisées comme un agent de sauvetage ou d'inversion, ou à titre prophylactique. L'invention est applicable en particulier à l'inversion des effets contraires des anesthétiques locaux délivrés systémiquement par inadvertance et à l'atténuation des effets thérapeutiques des anesthétiques généraux au cours du traitement.

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