Steroid sulphatase inhibitors

Details Steroid sulphatase inhibitors Steroid sulphatase inhibitors

A - Human Necessities

61

K

A61K 31/56 (2006.01) A61K 31/565 (2006.01) A61K 31/5685 (2006.01) C07C 307/02 (2006.01) C07J 41/00 (2006.01) C07J 43/00 (2006.01)

Patent

CA 2305758

Novel steroid sulphatase inhibitors are disclosed as well as pharmaceutical compositions containing them for use in the treatment of oestrone dependent tumours, especially breast cancer. The novel steroid sulphatase inhibitors are: sulphamate esters of formula (I), where R1 and R2 are each H, alkyl, alkenyl, cycloalkyl or aryl, or together represent an alkylene group optionally containing a heteroatom e.g. -O- or -NH-; and -O-polycycle represents the residue of a polycyclic alcohol, preferably a sterol, most preferably a 3-sterol. Preferred compounds are oestrone-3-sulphamate and N,N-dimethyl oestrone-3-sulphamate.

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