C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 14/165 (2006.01) A61K 39/215 (2006.01) C07K 7/06 (2006.01) G01N 33/53 (2006.01) G01N 33/569 (2006.01)
Patent
CA 2525778
In a first aspect the present invention consists of T cell epitopes in the Severe Acute Respiratory Syndrome (SARS) virus genome. More specifically there is provided 180 class I linear peptide epitopes and 200 class II linear epitopes from the SARS Virus genome. In a second aspect the invention also consists of variants of these sequences. In a third aspect this invention consists of a method to predict these sequences from genome data and to validate the predications experimentally. In a fourth aspect the present invention provides compositions including these epitopes for use in a vaccine and to induce a T cell response in a subject, or as a diagnostic tool.
Selon un premier aspect, l'invention concerne des épitopes de lymphocytes T situés dans le génome du virus du syndrome respiratoire aigu sévère (SRAS). Plus particulièrement, il existe 180 épitopes de peptides linéaires de classe I et 200 épitopes linéaires de classe II provenant du génome du virus du SRAS. Selon un deuxième aspect, l'invention concerne des variants de ces séquences. Selon un troisième aspect, l'invention concerne un procédé de prédiction de ces séquences à partir de données du génome et de validation des prédictions de manière expérimentale. Selon un quatrième aspect, l'invention concerne des compositions comprenant ces épitopes, destinées à être utilisées dans un vaccin et à induire une réaction des lymphocytes T chez un sujet, ou en tant qu'outil diagnostique.
Brunak Soren
Buus Soren
Justesen Sune
Lamberth Kasper
Lund Ole
Borden Ladner Gervais Llp
Brunak Soren
Buus Soren
Justesen Sune
Lamberth Kasper
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