G - Physics – 01 – N
Patent
G - Physics
01
N
G01N 33/564 (2006.01) G01N 33/535 (2006.01) G01N 33/573 (2006.01)
Patent
CA 2756073
The present invention relates to peptides biomarkers that are specifically recognized by autoantibodies present in the sera of patients with Rheumatoid Arthritis (RA). More specifically, the invention provides epitopes of PAD4, of BRAF, and of calpastatin as well as methods and kits for using these sequences for the diagnosis of RA, in particular for the diagnosis of RA in CCP-negative subjects.
La présente invention concerne des biomarqueurs peptidiques qui sont spécifiquement reconnus par des auto-anticorps présents dans le sérum de patients atteints de polyarthrite rhumatoïde (RA). Plus spécifiquement, l'invention concerne des épitopes de PAD4, de BRAF, et de la calpastatine ainsi que des procédés et des kits pour utiliser ces séquences pour le diagnostic de la RA, en particulier pour le diagnostic de la RA chez les patients CCP-négatifs.
Auger Isabelle
Roudier Jean
Inserm (institut de La Sante Et de La Recherche Medicale)
Inserm (institut National de La Sante Et de La Recherche Medical
Norton Rose Or S.e.n.c.r.l. S.r.l./llp
Universite de La Mediterranee - Aix-Marseille II
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