Chemical compounds

Details Chemical compounds Chemical compounds

A - Human Necessities

61

K

A61K 31/00 (2006.01)

Patent

CA 2297290

The invention concerns the use of a compound of formula (I), and their pharmaceutically acceptable salts or in vivo hydrolysable esters, in the treatment of a disease or condition mediated by monocyte chemoattractant protein-1 (MCP-1). Certain of the components of formula (I) are novel and are provided, together with pharmaceutical compositions thereof, as further features of the invention.

Cette invention concerne l'utilisation d'un composé de formule (I) dans laquelle Z, X, T, A, R?1¿, R?2¿, p et q possèdent le sens défini dans cette invention. Ces composés ainsi que leurs sels pharmaceutiquement acceptables ou que leurs esters hydrolysables in vivo sont utiles dans le traitement d'une maladie ou d'une pathologie induite par la protéine 1 chimiotactique de monocyte (MCP-1). Certains constituants de la formule (I) sont nouveaux et sont décrits ainsi que des compositions pharmaceutiques les contenant et que d'autres charactéristiques de cette invention.

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