C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/10 (2006.01) C12Q 1/68 (2006.01) G01N 33/554 (2006.01)
Patent
CA 2352463
A genetic package display system and methodology for probing protein-protein interactions that lead to cell transduction, selecting and/or identifying internalizing ligands, target cells and tissues which internalize known or putative ligands, and cell transduction facilitating peptides is provided. A ligand displaying genetic package that carries a selectable marker (e.g., reporter, selection, etc.) and presents a ligand on its surface is utilized to identify internalizing ligands, transduction facilitating peptides, and/or a variety of cells and tissue types for the ability to be successfully transduced by the ligand displaying genetic package.
L'invention concerne un système et une méthodologie d'expression sur matériel génétique, pour l'analyse d'interactions protéine-protéine induisant la transduction cellulaire, pour la sélection et/ou l'identification de ligands d'internalisation, de cellules cibles et de tissus qui internalisent des ligands connus ou putatifs, et de peptides facilitant la transduction cellulaire. Un matériel génétique exprimant un ligand, portant un marqueur pouvant être sélectionné (ex. reporter, sélection) et présentant un ligand sur sa surface, est utilisé pour l'identification de ligands d'internalisation, de peptides facilitant la transduction, et/ou de divers types de tissus et cellules pour leur capacité à être transduits avec succès par le matériel génétique d'expression de ligand.
Baird Andrew
Kassner Paul
Larocca David
Borden Ladner Gervais Llp
Selective Genetics Inc.
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