Compounds for treatment of inflammation, diabetes and...

Details Compounds for treatment of inflammation, diabetes and... Compounds for treatment of inflammation, diabetes and...

C - Chemistry, Metallurgy

07

D

C07D 213/56 (2006.01) A61K 31/165 (2006.01) A61K 31/425 (2006.01) A61K 31/56 (2006.01) A61K 31/64 (2006.01) A61P 3/06 (2006.01) A61P 3/10 (2006.01) A61P 9/06 (2006.01) A61P 35/00 (2006.01) C07C 235/30 (2006.01)

Patent

CA 2524780

Novel acyl urea, carbamate, thiocarbamate and related compounds are provided which are effective in inhibiting the cytokine-mediated inflammatory response in cultured cells, in ameliorating bone destruction in an animal model of arthritis and in lowering blood glucose levels in animal models of Type II diabetes mellitus. The compounds are disclosed as useful for a variety of treatments including the treatment of diabetes mellitus, insulin resistance, inflammation, inflammatory diseases, immunological diseases and cancer.

Cette invention concerne de nouveaux composés acyl urée, thiourée, carbamate, thiocarbamate et autres composés associés qui permettent d'inhiber la réponse inflammatoire induite par les cytokines dans des cellules en culture, d'améliorer la destruction osseuse dans un modèle animal de l'arthrite et de réduire les taux de glucose sanguin dans des modèles animaux de diabète de type II. Ces composés peuvent être utilisés pour une variété de traitements, y compris le traitement du diabète, de la résistance à l'insuline, de l'inflammation, des maladies inflammatoires, des maladies immunologiques et du cancer.

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