A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 38/18 (2006.01)
Patent
CA 2582224
The present invention relates to the fields of monitoring and modulating wound healing responses, controlling stem cell homingin vivo and tissue construction in vitro. Specifically, the present specification discloses that monitoring CCN3 expression during wound healing can be used for diagnostic purposes of detecting abnormal wound repair. The compositions blocking CCN3 activity for the methods of inhibiting wound repair are also disclosed, as well as compositions of expressing CCN3 polypeptide or its functional fragment for the methods of stimulating wound repair. Furthermore, the instant specification also discloses that CCN3 can be added to stem cells to retain the cells in a particular area and, therefore, accomplish stem cell homing. Finally, the instant invention also discloses that CCN3 polypeptide can be used for controlling cell migration during tissue construction in vitro
L'invention porte sur l'étude et la modulation des réponses en matière de cicatrisation des blessures et le suivi de la nostocytose des cellules souches <i>in vivo </i>et de la construction des tissus <i>in vitro </i>. Spécifiquement, l'invention révèle que le suivi de l'expression du CCN3 pendant la cicatrisation peut être utilisé à des fins diagnostiques pour détecter une réparation anormale des tissus. L'invention porte également: sur des compositions bloquant l'activité du CCN3 dans le processus d'inhibition de la cicatrisation; sur des compositions favorisant l'expression du CCN3 ou de ses fragments fonctionnels dans le processus de stimulation de la cicatrisation; et sur l'adjonction de CCN3 à des cellules souches pour retenir les cellules souches dans des zones particulières et donc accomplir leur nostocytose. L'invention révèle finalement que le CCN3 peut servir à réguler la migration des cellules lors de la construction des tissus <i>in vitro</i>
Lau Lester F.
Ridout & Maybee Llp
LandOfFree
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