Mda-7 protein variants having antiproliferative activity

Details Mda-7 protein variants having antiproliferative activity Mda-7 protein variants having antiproliferative activity

A - Human Necessities

61

K

A61K 48/00 (2006.01) G01N 1/10 (2006.01)

Patent

CA 2589644

The invention relates to the mda-7 gene, its encoded protein and fragments of the proteins. Several of these fragments of the MDA-7 protein exhibit antiproliferative activity and/or inhibited the activity of intact MDA-7. Accordingly, the invention provides, among other things, for methods and compositions that may be used in the treatment of disorders of cell proliferation, including cancer.

L'invention concerne le gène mda-7, sa protéine codée et des fragments de cette protéine. Plusieurs de ces fragments de la protéine MDA-7 présentent une activité antiproliférative et/ou inhibent l'activité de la MDA-7 intacte. Par conséquent, l'invention concerne également, entre autres, des méthodes et des compositions pouvant être utilisées dans le traitement de troubles liés à la prolifération cellulaire, y compris le cancer.

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