Treatment of inflammatory bowel disease

Details Treatment of inflammatory bowel disease Treatment of inflammatory bowel disease

A - Human Necessities

61

K

A61K 35/26 (2006.01) A61P 37/06 (2006.01) C12N 5/08 (2006.01)

Patent

CA 2619735

A method of treating inflammatory bowel disease (IBD) comprises collecting regulatory T cells in an activated or non-activated state from a patient's sentinel lypmph nodes draining bowel segments with or without IBD, optionally activating the cells by contacting them with a cytokine and an antigen extract obtained from an inflamed bowel segment, expanding the T cells in vitro, and re-infusing the expanded T cells to the patient. Also disclosed are methods for obtaining sentinel nodes, for expanding T cells, for re-establishing the TH1/TH2 balance in the patient suffering from Crohn's disease, and corresponding uses of the expanded T cells, the cytokines and of antigen extract, as well as of correspondingly activated and expanded T cells.

Un procédé de traitement de l~affection abdominale inflammatoire (IBD) comprenant la collecte de cellules régulatrices T à l~état activé ou non activé provenant des segments de drainage de l~intestin à ganglions sentinelles d~un patient atteint ou non par l~IBD, en activant de manière optionnelle les cellules en les mettant en contact avec une cytokine et un extrait d~antigène obtenu à partir d~un segment d~intestin présentant une inflammation, en déployant les cellules T in vitro et en réinfusant les cellules T déployées au patient. Sont également présentés des procédés d'obtention de ganglions sentinelles, de développement de cellules T, de rétablissement de l~équilibre TH1/TH2 chez le patient souffrant de la maladie de Crohn et les utilisations correspondantes des cellules T développées, les cytokines et l'extrait antigène ainsi que les cellules T correspondantes développées et activées.

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