Novel polymorphic forms of cipamfylline

Details Novel polymorphic forms of cipamfylline Novel polymorphic forms of cipamfylline

C - Chemistry, Metallurgy

07

D

C07D 473/16 (2006.01) A61K 31/52 (2006.01) C07D 473/18 (2006.01)

Patent

CA 2306980

This invention relates to novel crystalline polymorphic forms, Form I, II and IV of Cipamfylline, methods of preparation, and use thereof in the treatment of PDE4 and TNF mediated diseases. Cipamfylline is 1,3-di-cyclopropylmethyl-8- amino xanthine, and represented by formula (I).

La présente invention concerne de nouvelles formes polymorphes cristallines, Forme I, II et IV de la Cipamfylline, leurs procédés de préparation ainsi que leur utilisation dans le traitement des maladies véhiculées par PDE¿4? et TNF. La cipamfylline est constituée de 1,3-di-cyclopropylméthyl-8-amino xanthine et est représentée par la développée (I).

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