Cd2 binding domain of lymphocyte function associated antigen 3

Details Cd2 binding domain of lymphocyte function associated antigen 3 Cd2 binding domain of lymphocyte function associated antigen 3

C - Chemistry, Metallurgy

12

N

C12N 15/62 (2006.01) A61K 38/17 (2006.01) A61K 39/395 (2006.01) C07K 14/705 (2006.01) C07K 16/00 (2006.01) C07K 19/00 (2006.01) C12N 15/12 (2006.01) G01N 33/564 (2006.01) G01N 33/566 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2081028

Polypeptides and proteins comprising the CD2-binding domain of LFA-3 are disclosed, DNA sequences that code on expression for those polypeptides and proteins, methods of producing and using those polypeptides and proteins, and therapeutic and diagnostic compositions are also disclosed. Deletion mutants unable to bind CD2 and methods for their use are also disclosed. In addition, fusion proteins which comprise the CD2-binding domain of LFA-3 and a portion of a protein other than LFA-3, DNA sequences encoding those fusion proteins, methods for producing those fusion proteins, and uses of those fusion proteins are disclosed.

Polypeptides et protéines comportant le domaine de liaison de CD2 de l'antigène 3 associé à la fonction lymphocytaire (LFA-3); séquences d'ADN codant pour ces polypeptides et protéines lors de l'expression; procédés de production et d'utilisation de ces polypeptides et protéines; compositions thérapeutiques et diagnostiques; mutants de délétion incapables de se lier au CD2; procédés d'utilisation de ceux-ci; protéines fusionnées comportant le domaine de liaison de CD2 du LFA-3 et une partie d'une protéine autre que LFA-3; séquences d'ADN codant ces protéines fusionnées; procédés de production desdites protéines fusionnées; et applications de celles-ci.

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