Ursodeoxycholic acid-containing medicament in a liquid...

Details Ursodeoxycholic acid-containing medicament in a liquid... Ursodeoxycholic acid-containing medicament in a liquid...

A - Human Necessities

61

K

A61K 31/19 (2006.01) A61K 9/00 (2006.01) A61K 9/10 (2006.01) A61K 31/575 (2006.01)

Patent

CA 2130787

The active agent ursodeoxycholic acid has proved therapeutically active in infants, inter alia for the treatment of cholestatic hepatic diseases. A problem when administering this active agent, a bile acid, to infants is its extreme bitterness. As a result of the present invention a taste-acceptable, liquid administration form for ursodeoxycholic acid with an adequately high active agent concentration is described. The liquid to be ingested is a suspension prepared accompanied by the addition of a swelling and/or thickening agent, which contains the active agent mainly in fine crystalline form as the disperse phase and only in a much smaller proportion dissolved in the aqueous dispersant. A remaining residual bitterness can be additionally masked by the addition of .beta. -cyclodextrin or suitable taste correcting agents.

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