Methods and compositions for predicting, diagnosing and...

Details Methods and compositions for predicting, diagnosing and... Methods and compositions for predicting, diagnosing and...

A - Human Necessities

61

K

A61K 38/19 (2006.01) A61K 38/55 (2006.01) A61K 45/08 (2006.01) A61P 9/00 (2006.01) C12Q 1/24 (2006.01)

Patent

CA 2289365

This invention relates to a method of predicting those individuals at risk of developing lipodystrophy associated with antiretroviral therapy is disclosed. The method includes the steps of: (a) measuring CD36 levels in the patient prior to protease inhibitor or antiretroviral therapy; (b) measuring CD36 levels in the patient after initiating protease inhibitor or antiretroviral therapy; (c) determining whether CD36 levels after antiretroviral or protease inhibitor therapy are below the CD36 levels prior to therapy, the drop in CD36 levels being predictive of the subsequent development of lipodystrophy. The invention also includes a composition for treating or preventing lipodystrophy associated with PI or antiretroviral therapy. The composition includes PPAR.gamma.-RXR agonist to up-regulate CD36 in admixture with a pharmaceutically acceptable carrier, excipient, or diluent. The composition can be used in a method to prevent or treat lipodystrophy. The invention also includes a method of determining whether a test compound causes lipodystrophy in a mammal. 24

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