C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/60 (2006.01) C07K 14/805 (2006.01) C12N 9/00 (2006.01) C12N 9/88 (2006.01) C12N 15/12 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2268278
The present invention relates to recombinant hemoglobin solutions containing reduced amounts of protoporphyrin IX and to methods of producing such hemoglobin solutions. The methods are accomplished by overexpressing the hemH gene in a suitable host cell or by increasing the production of hemH in a host cell, for example, by integration of the hemH gene into the chromosome of the host cell or by inserting multiple copies of the gene in host cells naturally having a hemH gene.
La présente invention concerne des solutions d'hémoglobine recombinée contenant des quantités réduites de protoporphyrine IX, ainsi que des procédés de production de telles solutions d'hémoglobine. Les procédés selon l'invention consistent à surexprimer le gène hemH dans une cellule hôte appropriée, ou à augmenter la production de hemH dans une cellule hôte appropriée, ou à augmenter la production de hemH dans une cellule hôte, par exemple en intégrant le gène hemH dans le chromosome de la cellule hôte ou en introduisant plusieurs copies du gène dans des cellules hôtes comportant naturellement un gène hemH.
Best Elaine A.
Frye Christopher C.
Hershberger Charles L.
Baxter Biotech Technology S.a.r.l.
Eli Lilly And Company
Sim & Mcburney
Somatogen Inc.
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