Methods and compositions of targeted drug development

A - Human Necessities – 61 – K

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A61K 31/196 (2006.01) G06F 19/12 (2011.01) A61K 31/395 (2006.01) A61K 31/426 (2006.01) A61K 31/4406 (2006.01) C07K 1/00 (2006.01) C07K 14/71 (2006.01) C07K 16/00 (2006.01) C40B 30/02 (2006.01)

Patent

CA 2638905

The present invention is directed to methods for developing one or more drugs for one or more targeted therapies and compositions derived therefrom. In accordance with one aspect of the present invention, combinatorial chemistry techniques for use with high throughput screening techniques for identifying small molecule affinity and/or activity interactions are avoided by instead utilizing the natural mechanisms of antigen response to effect a massively parallel screening of naturally occurring molecules against an antigen. Other aspects of the invention provide compositions derived thereform as well as therapeutic methods of use for the compounds.

La présente invention concerne des procédés de développement d~un ou plusieurs médicaments pour un ou plusieurs traitements ciblés et des compositions dérivées de ceux-ci. Conformément à un aspect de l'invention, des techniques chimiques combinatoires destinées à une utilisation avec des techniques de criblage à haut débit servant à identifier une affinité de petites molécules et/ou des interactions d~activité sont évitées en utilisant à leur place les mécanismes naturels de réponse des antigènes en vue d~effectuer un criblage parallèle massif de molécules naturelles contre un antigène. Selon d'autres aspects, l~invention concerne des compositions qui en sont dérivées ainsi que des procédés d~utilisation thérapeutique des composés.

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