Determination of prodrugs metabolizable by the liver and...

Details Determination of prodrugs metabolizable by the liver and... Determination of prodrugs metabolizable by the liver and...

C - Chemistry, Metallurgy

12

Q

C12Q 1/26 (2006.01) A61K 31/505 (2006.01) A61K 31/52 (2006.01) A61K 31/53 (2006.01) A61K 31/70 (2006.01) C07H 19/04 (2006.01) G01N 33/50 (2006.01)

Patent

CA 2103050

2103050 9220816 PCTABS00017 A method of ascertaining if a prodrug is useful for treating a disease is disclosed. The prodrug is acceptable if it is metabolized in liver cells by aldehyde oxidase to produce an active drug or metabolite. Prodrugs are shown equally effective in treating diseases as the active drug itself with many benefits and without as many associated side effects. Methods for treating cancers with 5-iodo-2-pyrimidinone-deoxyribose and 5-fluoro-2-pyrimidinone are also described.

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