A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/12 (2006.01) A61K 31/047 (2006.01) A61K 31/075 (2006.01) A61K 31/122 (2006.01) A61K 31/21 (2006.01) A61K 31/33 (2006.01)
Patent
CA 2252519
A compound of formula (I) or (II) wherein R1 represents a lower alkyl; R2 represents H, an optionally substituted alkyl or an optionally substituted alkenyl; R3 and R4 each represents an optionally substituted lower alkyl or a lower alkoxy, or R3 and R4 form, taken together, an optionally substituted butadienylene; and X1 and X2 each represents an optionally esterified or etherified hydroxy, or a salt thereof is useful for protecting cells from the cytotoxicity of .beta.-amyloid protein.
L'invention concerne un composé de la formule (I) ou (II) dans lesquelles R?1¿ représente alkyle inférieur; R?2¿ représente H, un alkyle facultativement substitué ou un alcényle facultativement substitué; R?3¿ et R?4¿ représentent chacun un alkyle inférieur facultativement substitué ou un alcoxy inférieur, ou R?3¿ et R?4¿ forment, pris ensemble, un butadiénylène facultativement substitué; et X?1¿ et X?2¿ représentent chacun un hydroxy facultativement estérifié ou éthérifié, ou un sel de celui-ci. Le composé est utile pour protéger des cellules contre la cytotoxicité de la protéine .beta.-amyloïde.
Goto Giichi
Hirai Keisuke
Miyamoto Masaomi
Fetherstonhaugh & Co.
Takeda Chemical Industries Ltd.
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