Process for the preparation of a paclitaxel c-4 methyl...

Details Process for the preparation of a paclitaxel c-4 methyl... Process for the preparation of a paclitaxel c-4 methyl...

C - Chemistry, Metallurgy

07

D

C07D 305/14 (2006.01) C07F 7/18 (2006.01)

Patent

CA 2381401

A process for the synthesis of a C-4 methyl carbonate paclitaxel analog from 10-deacetylbaccatin III by the selective reduction of the acetate at the C-4 position of 10-deacetylbaccatin using Red-Al.

L'invention concerne un procédé de synthèse d'un analogue de carbonate de méthyle C-4 du paclitaxel, à partir de 10-déacétylbaccatine III, par réduction sélective de l'acétate sur la position C-4 de 10-déacétylbaccatine à l'aide de Red-Al.

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