Methods of treating nuclear factor-kappa b mediated diseases...

Details Methods of treating nuclear factor-kappa b mediated diseases... Methods of treating nuclear factor-kappa b mediated diseases...

C - Chemistry, Metallurgy

07

C

C07C 311/53 (2006.01) A61K 31/18 (2006.01) A61K 31/255 (2006.01) A61K 31/27 (2006.01) C07C 271/02 (2006.01) C07C 307/06 (2006.01)

Patent

CA 2369967

The present invention provides a method of treating a disease or a disorder responsive to inhibition of nuclear factor-kB transcription factors comprising administering to a patient in need thereof a sulfonylaminocarbonyl derivative, or a pharmaceutically acceptable salt thereof. The methods of the present invention are useful for treating, for example, rheumatoid arthritis, osteoarthritis, an autoimmune disease, psoriasis, asthma, a cardiovascular disease, an acute coronary syndrome, congestive heart failure, Alzheimer's disease, multiple sclerosis, cancer, type II diabetes, metabolic syndrome X, or inflammatory bowel disease.

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