Assay for parkinson's disease therapeutics and enzymatically...

Details Assay for parkinson's disease therapeutics and enzymatically... Assay for parkinson's disease therapeutics and enzymatically...

G - Physics

01

N

G01N 33/50 (2006.01) C12N 15/10 (2006.01)

Patent

CA 2632657

The invention provides to assays for agent useful for treatment of Parkinson's Disease. Included are cell-based assays for agents that modulate the effect of Parkin proteins on proteasome function. The invention also provides recombinant, enzymatically active, Parkin protein produced in prokaryotic expression systems, such as E. coli cells. Methods for purification of Parkin protein are also provided.

Cette invention concerne des analyses visant à identifier un agent utilisé dans le traitement de la maladie de Parkinson. Cette invention comprend des analyses sur cellules visant à identifier des agents qui modulent l'effet de protéines Parkines sur la fonction du protéasome. Cette invention concerne également une protéine Parkine enzymatiquement active de recombinaison produite dans des systèmes d'expression procaryotes tels que les cellules E. coli. Cette invention concerne également des méthodes de purification de protéine Parkine.

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