Method of preparing a protein aggregate and a pharmaceutical...

Details Method of preparing a protein aggregate and a pharmaceutical... Method of preparing a protein aggregate and a pharmaceutical...

A - Human Necessities

23

J

A23J 3/16 (2006.01) A61K 9/16 (2006.01) A61K 47/42 (2006.01)

Patent

CA 2560076

The invention relates to a method of preparing a protein aggregate, wherein an aqueous protein solution is acidified with a pH that lies above the isoelectric point of the protein. In accordance with the invention, a first protein, which through acidificaiton is able to form a protein aggregate, is acidified in the presence of a second protein in the aqueous solution in order to form a coaggregate comprising the first and second protein, wherein the second protein under identical temperature conditions and pH does not form a protein aggregate in the absence of the first protein. Acidification preferably occurs with the aid of CO2.

La présente invention concerne une techniques de préparation d'un agrégat de protéines dans laquelle une solution de protéines aqueuses est acidifiée avec un pH situé au-dessus du point isoélectrique de la protéine. Selon cette invention, une première protéine, qui via l'acidification est capable de former un agrégat de protéines, est acidifiée en présence d'une seconde protéine dans la solution aqueuse de façon à former un agrégat comprenant la première et la seconde protéine, la seconde protéine dans des conditions de température et de pH identiques ne formant pas un agrégat de protéines en l'absence de la première protéine. L'acidification survient de préférence avec l'aide de CO¿2?.

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