Antibodies against the muc18 antigen

C - Chemistry – Metallurgy – 07 – K

Patent

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Details

C07K 16/30 (2006.01) A61K 39/395 (2006.01) A61K 47/48 (2006.01) C07K 16/28 (2006.01)

Patent

CA 2471849

The present invention relates generally to the generation and characterization of anti-MUC18 monoclonal antibodies. The invention further relates to the use of such anti-MUC18 antibodies in the diagnosis and treatment of disorders associated with increased activity of MUC18, in particular, tumors, such as melanomas.

Cette invention se rapporte d'une façon générale à la production et à la caractérisation d'anticorps monoclonaux anti-MUC18. Cette invention concerne en outre l'utilisation de ces anticorps anti-MUC18 dans le diagnostic et le traitement des affections associées à une activité accrue de MUC18, en particulier des tumeurs, telles que les mélanomes.

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