C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 401/14 (2006.01) A61K 31/4155 (2006.01) A61K 31/4188 (2006.01) A61K 31/4196 (2006.01) A61K 31/428 (2006.01) A61K 31/4709 (2006.01) A61K 31/501 (2006.01) A61P 1/04 (2006.01) A61P 3/04 (2006.01) A61P 3/06 (2006.01) A61P 3/10 (2006.01) A61P 9/04 (2006.01) A61P 9/12 (2006.01) A61P 11/06 (2006.01) A61P 17/00 (2006.01) A61P 25/00 (2006.01) A61P 25/14 (2006.01) A61P 25/16 (2006.01) A61P 25/18 (2006.01) A61P 25/24 (2006.01) A61P 25/28 (2006.01) A61P 37/08 (2006.01) A61P 43/00 (2006.01) C07D 403/14 (2006.01) C0
Patent
CA 2692249
It is to provide a novel pyrazolone derivative represented by the following general formula (1), which is useful as a pharmaceutical and has a phosphodiesterase inhibitory action: (see formula 1) wherein R1,R2: C1-6 alkyl; R3,R4: H, X, C1-6 alkoxy; Z:O, S; A:AA, BB, wherein AA represents (see formula II) wherein BB represents (see formula III) wherein R5: H, C1-6 alkyl ; R6,R7: C1-6 alkyl.
La présente invention concerne un nouveau dérivé de pyrazolone représenté par la formule générale (I) ci-dessous, qui est utile comme produit pharmaceutique ayant une activité inhibitrice de la phosphodiestérase. (1) R1, R2 : alkyle en C1 à C6, R3, R4 : H, X, alcoxy en C1 à C6, Z : O, S, A : AA, BB (R5 : H, alkyle en C1 à C6 ; R6, R7 : alkyle en C1 à C6).
Kishi Tetsuya
Kohno Yasushi
Ochiai Koji
Takita Satoshi
Kyorin Pharmaceutical Co. Ltd.
Norton Rose Or S.e.n.c.r.l. S.r.l./llp
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