1, 2, 4 -oxadiazole compounds for the treatment of...

C - Chemistry – Metallurgy – 07 – D

Patent

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

C07D 413/04 (2006.01) A61K 31/553 (2006.01) A61P 37/00 (2006.01) C07D 413/14 (2006.01)

Patent

CA 2710055

The present invention relates to novel oxadiazole derivatives of formula (I) or a pharmaceutically acceptable salt thereof thereof. Compounds of formula (I) and their pharmaceutically acceptable salts are of use in the treatment of conditions or disorders which are mediated via the S1 P1 receptor. In particular the compounds of formula (I) and their pharma-ceutically acceptable salts are of use in the treatment of multiple sclerosis, autoimmune diseases, chronic inflammatory disorders, asthma, inflammatory neuropathies, arthritis, transplantation, Crohn's disease, ulcerative colitis, lupus erythematosis, psoriasis, ischemia-reperfusion injury, solid tumours, and tumour metastasis, diseases associated with angiogenesis, vascular diseases, pain conditions, acute viral diseases, inflammatory bowel conditions, insulin and non-insulin dependant diabetes.

La présente invention porte sur de nouveaux dérivés d'oxadiazoles représentés par la formule (I) ou sur un sel pharmaceutiquement acceptable de ceux-ci. Les composés représentés par la formule (I) et leurs sels pharmaceutiquement acceptables sont utiles dans le traitement d'états ou de troubles qui sont à médiation par le récepteur S1P1. En particulier, les composés représentés par la formule (I) et leurs sels pharmaceutiquement acceptables sont utiles dans le traitement de la sclérose en plaque, de maladies auto-immunes, de troubles inflammatoires chroniques, de l'asthme, de neuropathies inflammatoires, de l'arthrite, d'une transplantation, de la maladie de Crohn, de la rectocolite hémorragique, d'un lupus érythémateux, du psoriasis, d'une lésion d'ischémie-reperfusion, de tumeurs solides et d'une métastase tumorale, de maladies associées à l'angiogénèse, de maladies vasculaires, d'états pathologiques douloureux, de maladies virales aiguës, d'affections intestinales inflammatoires, du diabète insulinodépendant et non insulinodépendant.

LandOfFree

Say what you really think

Search LandOfFree.com for Canadian inventors and patents. Rate them and share your experience with other people.

Rating

1, 2, 4 -oxadiazole compounds for the treatment of... does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with 1, 2, 4 -oxadiazole compounds for the treatment of..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and 1, 2, 4 -oxadiazole compounds for the treatment of... will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFCA-PAI-O-1500875

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.