1-aryl-4-substituted piperazine derivatives for use as ccr1...

Details 1-aryl-4-substituted piperazine derivatives for use as ccr1... 1-aryl-4-substituted piperazine derivatives for use as ccr1...

C - Chemistry, Metallurgy

07

D

C07D 487/04 (2006.01) A61K 31/496 (2006.01) A61K 31/497 (2006.01) A61K 31/506 (2006.01) A61K 31/52 (2006.01) A61K 31/5513 (2006.01) A61P 29/00 (2006.01) A61P 37/00 (2006.01) C07D 231/12 (2006.01) C07D 231/14 (2006.01) C07D 231/16 (2006.01) C07D 231/18 (2006.01) C07D 231/38 (2006.01) C07D 231/56 (2006.01) C07D 233/54 (2006.01) C07D 235/06 (2006.01) C07D 241/04 (2006.01) C07D 243/08 (2006.01) C07D 249/12 (2006.01) C07D 257/04 (2006.01) C07D 401/12 (2006.01) C07D 401/14 (2006.01) C07D 403/06 (2006.01) C07D 403

Patent

CA 2488202

Compounds are provided that act as potent antagonists of the CCR1 receptor, and which have been further confirmed in animal testing for inflammation, one of the hallmark disease states for CCR1. The compounds are generally aryl piperazine derivatives and are useful in pharmaceutical compositions, methods for the treatment of CCR1-mediated diseases, and as controls in assays for the identification of competitive CCR1 antagonists.

L'invention concerne des composés qui agissent en tant qu'antagonistes efficaces du récepteur CCR1, et dont l'efficacité a été confirmée dans des tests sur des animaux pour l'inflammation, une des marques des états pathologiques associés au CCR1. Lesdits composés sont de manière générale des dérivés de pipérazine aryle et sont utilisés dans des compositions pharmaceutiques, dans des méthodes de traitement pour des maladies associées au CCR1, et utilisés en tant que témoins dans des essais biologiques pour identifier les antagonistes du CCR1.

Affiliated with

Also associated with

Rating

1-aryl-4-substituted piperazine derivatives for use as ccr1... does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with 1-aryl-4-substituted piperazine derivatives for use as ccr1..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and 1-aryl-4-substituted piperazine derivatives for use as ccr1... will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFCA-PAI-O-1393205