18, 21-didesoxymacbecin derivatives for the treatment of cancer

Details 18, 21-didesoxymacbecin derivatives for the treatment of cancer 18, 21-didesoxymacbecin derivatives for the treatment of cancer

C - Chemistry, Metallurgy

07

D

C07D 225/06 (2006.01) A61K 31/395 (2006.01) A61P 35/00 (2006.01)

Patent

CA 2669054

The present invention relates to macbecin analogues that are useful, e.g. in the treatment of cancer, B-cell malignancies, malaria, fungal infection, diseases of the central nervous system and neurodegenerative diseases, diseases dependent on angiogenesis, autoimmune diseases and/or as a prophylactic pre-treatment for cancer. The present invention also provides methods for the production of these compounds involving incorporation of non-natural starter units and their use in medicine, in particular in the treatment and / or prophylaxis of cancer or B-cell malignancies.

La présente invention concerne des analogues de macbécine trouvant une utilité, par exemple, dans le traitement du cancer, de tumeurs malignes des lymphocytes B, de la malaria, d'une infection fongique, de maladies du système nerveux central et de maladies neurodégénératives, de maladies dépendant de l'angiogenèse ou de maladies auto-immunes, et/ou comme traitement préventif du cancer. La présente invention concerne également des procédés de production de ces composés, par incorporation d'unités de départ non naturelles, ainsi que l'utilisation desdits composés en médecine, notamment dans le traitement et/ou la prévention du cancer ou de tumeurs malignes des lymphocytes B.

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