2-aminopyridine derivatives, their use as medicines and...

C - Chemistry – Metallurgy – 07 – D

Patent

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Details

C07D 213/73 (2006.01) A61K 31/44 (2006.01) A61K 31/495 (2006.01) C07C 233/44 (2006.01) C07C 271/22 (2006.01) C07D 401/04 (2006.01) C07D 405/12 (2006.01)

Patent

CA 2337258

The invention concerns novel 2-aminopyridine derivatives having an activity inhibiting NO-synthase enzymes producing nitrogen monoxide NO and/or trapping reactive forms of oxygen, the methods for preparing them, pharmaceutical compositions containing them and their therapeutic uses, particularly their use as NO-synthase inhibitors and for trapping reactive forms of oxygen whether selectively or not.

L'invention a pour objet des nouveaux dérivés de 2-aminopyridines présentant une activité inhibitrice des enzymes NO-synthases produisant le monoxyde d'azote NO et/ou une activité piégeuse des formes réactives de l'oxygène, leurs méthodes de préparation, les préparations pharmaceutiques les contenant et leur utilisation à des fins thérapeutiques, en particulier leur utilisation en tant qu'inhibiteurs des NO-synthases et piégeurs de formes réactives de l'oxygène de manière sélective ou non.

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