8-hydroxyquinoline compounds and methods thereof

Details 8-hydroxyquinoline compounds and methods thereof 8-hydroxyquinoline compounds and methods thereof

C - Chemistry, Metallurgy

07

D

C07D 215/16 (2006.01) A61K 31/47 (2006.01) C07D 401/04 (2006.01)

Patent

CA 2659952

The present invention relates to 8-Hydroxyquinoline Compounds; compositions comprising an 8-Hydroxyquinoline Compound; and methods for treating or preventing a metalloproteinase-related disorder, such as, an arthritic disorder, osteoarthritis, malignant neoplasm, rheumatoid arthritis, asthma, chronic obstructive pulmonary disease, atherosclerosis, age-related macular degeneration, myocardial infarction, a corneal ulceration, an ocular surface disease, hepatitis, an aortic aneurysm, tendonitis, a central nervous system disorder, abnormal wound healing, angiogenesis, restenosis, cirrhosis, multiple sclerosis, glomerulonephritis, graft versus host disease, diabetes, an inflammatory bowel disease, shock, invertebral disc degeneration, stroke, osteopenia or a periodontal disease or comprising administering an effective dose of an 8-Hydroxyquinoline Compound to a mammal in need thereof.

La présente invention concerne des composés de 8-hydroxyquinoléine ; des compositions comprenant un composé de 8-hydroxyquinoléine ; et des procédés servant à traiter ou à prévenir un trouble lié aux métalloprotéinases, tel qu'une maladie arthritique, l'arthrose, un néoplasme malin, la polyarthrite rhumatoïde, l'asthme, une bronchopneumopathie chronique obstructive, l'athérosclérose, la dégénérescence maculaire liée à l'âge, l'infarctus du myocarde, un ulcère cornéen, une maladie de la surface de l'AEil, l'hépatite, un anévrisme de l'aorte, une tendinite, une maladie du système nerveux central, une cicatrisation de plaie anormale, l'angiogenèse, la resténose, la cirrhose, la sclérose en plaques, la glomérulonéphrite, la réaction de greffe contre hôte, le diabète, une maladie abdominale inflammatoire, un choc, une dégénérescence de disques intervertébraux, une attaque, l'ostéopénie ou une parodontopathie, ou consistant à administrer une dose efficace d'un composé de 8-hydroxyquinoléine à un mammifère qui en a besoin.

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