A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/65 (2006.01) A61K 9/16 (2006.01) A61P 31/04 (2006.01)
Patent
CA 2533150
The present invention is a solid dosage form of a doxycycline metal complex. The present invention also includes a process for making a doxycycline metal complex in a solid dosage form. The process comprises the steps of (i) providing an aqueous solution of doxycycline or a physiologically acceptable salt thereof; (ii) admixing a metal salt with the aqueous solution; (iii) admixing a base to increase the pH of the aqueous solution, thereby forming a suspension of doxycycline metal; and (iv) drying the suspension, thereby forming a dry granulation of doxycycline metal complex.
La présente invention concerne une forme posologique solide d'un complexe métallique de doxycycline. La présente invention concerne également un procédé de fabrication d'un complexe métallique de doxycycline en une forme posologique solide. Ce procédé consiste (i) à utiliser une solution aqueuse de doxycycline ou un sel physiologiquement acceptable correspondant, (ii) à mélanger un sel métallique avec cette solution aqueuse, (iii) à ajouter une base en vue d'augmenter le pH de la solution aqueuse, ce qui permet de former une suspension de métal de doxycycline, et (iv) à sécher la suspension, d'où la formation d'un granule sec d'un complexe métallique de doxycycline.
Devries Tina M.
Gold Lynn
Sim & Mcburney
Warner Chilcott Company Inc.
Warner Chilcott Company Llc
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