Amidine derivatives for treating amyloidosis

Details Amidine derivatives for treating amyloidosis Amidine derivatives for treating amyloidosis

C - Chemistry, Metallurgy

07

D

C07D 263/14 (2006.01) A61K 31/155 (2006.01) A61K 31/341 (2006.01) A61K 31/343 (2006.01) A61K 31/4164 (2006.01) A61K 31/4178 (2006.01) A61K 31/4184 (2006.01) A61K 31/421 (2006.01) C07D 213/14 (2006.01) C07D 401/04 (2006.01) C07D 403/14 (2006.01) C07D 405/04 (2006.01) C07D 409/14 (2006.01) C07D 413/04 (2006.01)

Patent

CA 2488493

The present invention relates to the use of amidine compounds in the treatment of amyloid related diseases. In particular, the invention relates to a method of treating or preventing an amyloid-related disease in a subject comprising administering to the subject a therapeutic amount of an amidine compound. Among the compounds for use according to the invention are those according to the following Formulae, such that, when administered, amyloid fibril formation, neurodegeneration, or cellular toxicity is reduced or inhibited. Formula I, Formula II, Formula III.

La présente invention se rapporte à l'utilisation de composés d'amidine pour le traitement de maladies associées aux amyloïdes. En particulier, l'invention se rapporte à une méthode de traitement ou de prévention d'une maladie associée aux amyloïdes chez un sujet, qui consiste à administrer audit sujet une dose thérapeutique d'un composé d'amidine. Parmi les composés pouvant être utilisés dans le cadre de cette invention, on trouve les composés représentés par les formules suivantes, qui permettent, lorsqu'ils sont administrés, de réduire ou d'inhiber la formation de fibrilles amyloïdes, la neurodégénérescence ou la toxicité cellulaire.

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