Aqueous spectinomycin borate solutions

Details Aqueous spectinomycin borate solutions Aqueous spectinomycin borate solutions

C - Chemistry, Metallurgy

07

F

C07F 5/04 (2006.01) A61K 31/69 (2006.01) C07F 5/02 (2006.01)

Patent

CA 2214327

Aqueous pharmaceutical compositions containing more than 10 % spectinomycin, prepared by the reaction of the ketone hydrate of spectinomycin with boric acid to form the boron compound, and with a base such as sodium hydroxyde to form the stable salt of the compound. Method for preparing same and new boron compound of spectinomycin and salt thereof.

La présente invention concerne des compositions pharmaceutiques aqueuses contenant plus de 10 % de spectinomycine, préparées par mise en réaction de l'hydrate de cétone de spectinomycine avec de l'acide borique pour former le composé de bore, et avec une base telle que l'hydroxyde de sodium pour former le sel stable du composé. L'invention porte aussi sur le procédé de préparation de celui-ci et du nouveau composé au boré de la spectinomycine et d'un sel de celui-ci.

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