Azaheterocyclyl derivatives of androstanes and androstenes...

Details Azaheterocyclyl derivatives of androstanes and androstenes... Azaheterocyclyl derivatives of androstanes and androstenes...

C - Chemistry, Metallurgy

07

J

C07J 43/00 (2006.01) A61K 31/565 (2006.01) A61K 31/58 (2006.01) A61P 9/04 (2006.01)

Patent

CA 2649173

Compounds of formula (I) wherein: the groups are as defined in the description, are useful for the preparation of medicaments for the treatment of cardiovascular disorders, in particular heart failure and hypertension. The compounds are inhibitors of the enzymatic activity of the Na+,K+-ATPase. They are useful for the preparation of a medicament for the treatment of a disease caused by the hypertensive effects of endogenous ouabain, such as renal failure progression in autosomal dominant polycystic renal disease (ADPKD), preeclamptic hypertension and proteinuria and renal failure progression in patients with adducin polymorphisms.

L'invention concerne des composés de formule (I) dans laquelles les groupes sont tels que définis dans le descriptif, qui sont utilisés pour la préparation de médicaments pour le traitement de troubles cardio-vasculaires, en particulier l'insuffisance cardiaque et l'hypertension. Les composés sont des inhibiteurs de l'activité enzymatique de Na+, K+-ATPase. On les utilise pour préparer un médicament destiné au traitement d'une maladie provoquée par les effets d'hypertension de l'ouabaïne endogène, par exemple la progression de l'insuffisance rénale dans la maladie rénale polycystique autosomique dominante (ADPKD), l'hypertension prééclamptique et la protéinurie et la progression de l'insuffisance rénal chez les patients présentant des polymorphismes de l'adducine.

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