C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 213/38 (2006.01) A61K 31/345 (2006.01) A61K 31/505 (2006.01) A61P 3/10 (2006.01) C07D 213/30 (2006.01) C07D 239/26 (2006.01)
Patent
CA 2543247
This invention relates to compounds of the formula (I) wherein R6 and R7 is formula (II) R4 and R5 or R5 and R6 together with the carbon atoms to which they are attached, form a ring as defined in the description and X1, X2, Y1 to Y4, R1 to R13 and n are as specified in the description, and to all enantiomers and pharmaceutically acceptable salts and/or esters thereof. The invention further relates to pharmaceutical compositions containing such compounds, to a process for their preparation and to their use for the treatment and/or prevention of diseases which are modulated by PPAR.delta. and/or- PPAR.alpha. agonists.
L'invention concerne des composés de formule (I), ainsi que tous les énantiomères et les sels et/ou esters pharmaceutiquement acceptables de ces composés. Dans la formule (I), R?6¿ et R?7¿ représentent un groupe de formule (II), R?4¿ et R?5¿ ou R?5¿ et R?6¿ forment, avec les atomes de carbone auxquels ils sont liés, un cycle tel que défini dans la description et X?1¿, X?2¿, Y?1¿ à Y?4¿, R?1¿ à R?13¿ et n ont les significations indiquées dans la description. L'invention concerne en outre des compositions pharmaceutiques contenant de tels composés, un procédé de préparation desdits composés et leur utilisation en traitement et/ou prévention de maladies modulées par des agonistes de PPAR.delta. et/ou PPAR.alpha..
Ackermann Jean
Aebi Johannes
Binggeli Alfred
Grether Uwe
Hirth Georges
F. Hoffmann-La Roche Ag
Gowling Lafleur Henderson Llp
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