Chimeric vaccine antigens against the avian influenza virus

Details Chimeric vaccine antigens against the avian influenza virus Chimeric vaccine antigens against the avian influenza virus

C - Chemistry, Metallurgy

07

K

C07K 19/00 (2006.01) A61K 39/145 (2006.01) A61K 39/385 (2006.01) A61P 31/16 (2006.01) A61P 37/02 (2006.01) C07K 14/11 (2006.01) C07K 14/705 (2006.01)

Patent

CA 2638832

The present invention describes chimeric vaccine antigens against the avian influenza virus (AIV). Said vaccine antigens are based on viral subunits that are coupled to protein molecules that stimulate not only the cellular but also the humoral immune system. The chimeric antigens may be produced in expression systems that guarantee correct three-dimensional folding of the chimeric molecules that constitute the basis of the present invention. The vaccine compositions that contain said chimeric antigens induce a potent, early immune response both in birds and in vaccinated mammals, stimulating high haemagglutinin-inhibiting antibody titres and a potent specific cellular response against the viral antigen. The chimeric antigens, and also the resulting vaccine compositions, are applicable to the field of human and animal health as vaccines for preventive use.

L'invention concerne des antigènes vaccinaux chimères utilisés contre le virus de la grippe aviaire (IA). Ces antigènes vaccinaux sont basés sur des sous-unités virales couplées à des molécules protéiques stimulatrices du système immunitaire, tant sur le plan cellulaire qu'humoral. Les antigènes chimères peuvent être produits dans des systèmes d'expression qui garantissent un pliage tridimensionnel correct des molécules chimères qui constituent la base de cette invention. Les compositions de vaccin contenant ces antigènes chimères induisent une réponse immunitaire puissante et rapide tant chez les oiseaux que chez les mammifères vaccinés, stimulant des titres élevés d'anticorps inhibiteurs de l'hémagglutination et une réponse cellulaire spécifique puissante contre l'antigène viral. Les antigènes chimères, ainsi que les compositions de vaccins obtenus peuvent être appliqués au domaine de la santé humaine et animale, en tant que vaccins préventifs.

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