C - Chemistry – Metallurgy – 12 – Q
Patent
C - Chemistry, Metallurgy
12
Q
C12Q 1/68 (2006.01)
Patent
CA 2450403
The examination of mutations in the entire mitochondrial genome is used as a diagnostic system for diseases such as prostate cancer, and non melanoma skin cancer. Characteristic mutations and rearrangements including, point mutations (transitions, transversions), deletions, inversions, duplications, recombinations, insertions or combinations thereof in the mitochondrial genome are used as early indicators of prostate cancer, and non melanoma skin cancer. Moreover, the 4977bp, or "common deletion" as well as other associated mutations and/or deletions are used as a measure of aging.
L'examen de mutations dans l'ensemble du génome mitochondrial sert de système diagnostique pour des maladies telles que le cancer de la prostate et le cancer de la peau sans mélanomes. Des mutations et des réarrangements caractéristiques tels que des mutations ponctuelles (transitions, transversions), délétions, inversions, duplications, recombinaisons, insertions ou des combinaisons de celles-ci dans le génome mitochondrial servent d'indicateurs précoces du cancer de la prostate et du cancer de la peau sans mélanomes. Par ailleurs, 4977bp ou <= délétion commune >= ainsi que d'autres mutations et/ou délétions associées servent de mesure du vieillissement.
Birch-Machin Mark
Dakubo Gabriel D.
Ngom Alioune
Parr Ryan
Th'ng John
1304854 Ontario Ltd.
Blake Cassels & Graydon Llp
LandOfFree
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