C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/24 (2006.01) C07K 14/715 (2006.01) C07K 16/24 (2006.01) C07K 17/00 (2006.01) C12N 1/21 (2006.01) C12N 5/10 (2006.01) C12N 15/00 (2006.01) C12N 15/19 (2006.01) C12N 15/63 (2006.01) C12N 15/85 (2006.01) C12P 21/02 (2006.01)
Patent
CA 2482368
Novel methods are disclosed for forming a heterodimeric receptor complex with IL-28r AND CRF2-4. The methods may be used for detecting and treating viral infections in in vitro and in vivo. Ligand-binding receptor polypeptides can also be used to block ligand activity in vitro and in vivo. The present invention also includes methods for producing the protein, uses therefor and antibodies thereto.
La présente invention concerne de nouvelles méthodes de formation d'un complexe de récepteur hétérodimère avec IL-28r et CRF2-4. Les méthodes selon l'invention peuvent être utilisées pour détecter et traiter les infections virales in vitro et in vivo. Des polypeptides du récepteur se liant au ligand peuvent également être utilisés pour bloquer l'activité du ligand in vitro et in vivo. Cette invention concerne également des méthodes de production de la protéine, les utilisations correspondantes et les anticorps associés.
Grant Francis J.
Kindsvogel Wayne R.
Klucher Kevin M.
Novak Julia E.
Presnell Scott R.
Bristol-Myers Squibb Company
Norton Rose Or S.e.n.c.r.l. S.r.l./llp
Zymogenetics Inc.
Zymogenetics Llc
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