A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 51/10 (2006.01) A61K 39/395 (2006.01) A61P 35/00 (2006.01) G01N 33/574 (2006.01) G01N 33/577 (2006.01)
Patent
CA 2666464
This invention relates to the diagnosis and treatment of cancerous diseases, particularly to the mediation of cytotoxicity of primary and metastatic human tumor cells; and most particularly to the use of an isolated monoclonal antibody or cancerous disease modifying antibodies (CDMAB) thereof, optionally in combination with one or more chemotherapeutic agents, as a means for initiating the cytotoxic response in such human tumors, e.g. any primary or metastatic tumor sites which arise from hepatocytes. The invention further relates to binding assays which utilize the CDMAB of the instant invention.
Cette invention concerne le diagnostic et le traitement de maladies cancéreuses, notamment la médiation de cytotoxicité de cellules tumorales humaines primaires et métastatiques. L'invention concerne plus particulièrement l'utilisation d'un anticorps monoclonal isolé ou de certains de ces anticorps modifiant la maladie cancéreuse (CDMAB), éventuellement en association avec un ou plusieurs agents chimiothérapiques, comme moyen pour amorcer la réponse cytotoxique chez de telles tumeurs humaines, par exemple tous sites tumoraux primaires ou métastatiques survenant à partir d'hépatocytes. L'invention concerne en outre des dosages de liaison qui utilisent le CDMAB de l'invention.
Dacruz Luis A. G.
Fan Sheung Tat
Findlay Helen P.
Hahn Susan E.
Lee Terence Kin Wah
F. Hoffmann-La Roche Ag
Gowling Lafleur Henderson Llp
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